Currents from inside the Pharmacy Practise and LearningAsma El-Magboub, Ian S

Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>

Physical goals and you will pharmacology out of curcumin

Guide ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the big component of the fresh new reddish dye off turmeric, an enthusiastic Indian spruce that’s taken from the fresh rhizome of one’s warm bush Curcuma longa, which belongs to the Zingiberaceae friends. Within chapter, we talk about the pharmacological facts from curcumin and you may talk about new molecular bases for these facts. We then opinion the shown and you can potential systematic spends of curcumin. Curcumin is known usually since a therapeutic representative, however, the procedure out-of step try outlined. The new pharmacological negative effects of curcumin seem to be the consequence of a good synergism regarding sites from weak biochemical interactions that have numerous physical aim into the interrelated signaling paths. Such goals include enzymes like cyclooxygenase, lipoxygenase and you may healthy protein kinases, and transcription activities for example NF-?B, STAT and you may Nrf2. Modulation of those particles affects downstream affectors that make brand new antiinflammatory, antioxidant, chemopreventive, anticancer, and you will antimicrobial activities off curcumin. This type of consequences was basically checked in the medical examples regarding curcumin having problems and you may inflammatory ailment, cancer, Alzheimer condition, aerobic illness, and you may diabetes. This new trials purchased adjustable doses of curcuminwith different frequencies and you will duration, on standard conclusion one to highest doses away from curcumin on level of grams are required to receive healing outcomes. Read more

Curcumin: Synthesis, Emerging Part when you look at the Serious pain Government and you will Health Ramifications

Guide Part Examples of bush-derived pharmaceuticals that have end up being the interest off proceeded and great browse and innovation notice keeps, up until now, started quite scarce. Once a long period, the last twenty years was basically characterized by good 100-flex escalation in just how many medical blogs authored per year one to try regarding benefits on usage of curcumin when you look at the biomedicine. Read more

Structure, synthesis and you will physical points out of curcumin prodrugs

Publication ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, colombiansk-bГёrne-datingside Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has some prospective pharmacological outcomes that will possess therapeutic software in several situation claims, because chatted about in more detail in the last chapter. But not, the possibility medical efficacy off curcumin is limited by the its physicochemical services out of bad liquids solubility and you may imbalance, which trigger low bioavailability. Prodrugs off curcumin promote a means to update of your own biopharmaceutical and pharmacokinetic features, and can even succeed exploitation of the pharmacological effects of curcumin. Contained in this part, we basic comment the fresh physicochemical and you can pharmacokinetics of curcumin. We next explain the style of curcumin prodrugs that have increased drinking water solubility and you can increased agents balance which is often translated to totally free curcumin on bioactivation in vivo. I emphasize current profits in this area, with a concentrate on the design, synthesis and research of prodrugs according to promoieties along with proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and polymeric content instance hyaluronic acid and you can polyethylene glycol. It section gets the reason for optimization of the physicochemical and you can biopharmaceutical qualities and the biological facts off curcumin prodrugs, to your objective using of these curcumin types in systematic programs. Find out more